Amino Silane

A provision for the use of structure activity relationships (SAR) to reduce testing needs is included under EPA’s HPV Challenge Program. Specifically, categories may be formed based on structural similarity, through analogy, or through a combination of category and analogy for use with single chemicals. The benefits of using a category approach are numerous and include(1) accelerated release of hazard information to the public, as category analysis and testing is proposed to be initiated within the first two years of the HPV Program;(2) reduction in the number of animals used for testing; and (3) an economic savings as a result of a reduced testing program.
Two amino silane materials proposed to be categorized based on structural similarity are:
•  1-Propanamine, 3-(triethoxysilyl)- (CAS No. 919-30-2)
•  1,2-Ethanediamine, N-[3-(trimethoxysilyl) propyl]- (CAS No. 1760-24-3).  
Both of these amino silanes are listed as HPV Challenge Program chemicals. The development of this amino silane category follows current EPA guidance1